January 1, 2006Hormone Research in Paediatrics

Growth Hormone and Prolactin Receptors in Adipogenesis: STAT-5 Activation, Suppressors of Cytokine Signaling, and Regulation of Insulin-Like Growth Factor I

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Population

3T3-L1 preadipocytes

Comparison

Mouse growth hormone and mouse prolactin vs Undifferentiated vs differentiating cells

Design

Preclinical

Authors

DFDon FleenorDuke University RARamamani ArumugamUniversity of Massachusetts Chan Medical School MFMichael FreemarkDuke University

Discussion

Member takes

Implication

Differential PRL/GH signaling in adipogenesis warrants targeted metabolic studies; animal data leave open human translation and should not alter practice.

Structured PICO

Population

3T3-L1 preadipocytes

Intervention

Mouse growth hormone (mGH) and mouse prolactin (mPRL)

Comparator

Undifferentiated vs differentiating cells

Outcome

Expression of GHR and PRLR mRNAs, STAT-5 activity, SOCS-1-3, CIS, and IGF-I mRNAsurrogate

Somatogens and lactogens regulate adipocyte development and fat metabolism through distinct but overlapping cellular mechanisms, driven by disparities in receptor expression during differentiation.

Cite This Study

Fleenor et al. (2006) studied this question.

synapsesocial.com/papers/6a8a7b449be9d02581bdb5b2 https://doi.org/10.1159/000093667

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Implication

Differential PRL/GH signaling in adipogenesis warrants targeted metabolic studies; animal data leave open human translation and should not alter practice.

Growth Hormone and Prolactin Receptors in Adipogenesis: STAT-5 Activation, Suppressors of Cytokine Signaling, and Regulation of Insulin-Like Growth Factor I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Growth Hormone and Prolactin Receptors in Adipogenesis: STAT-5 Activation, Suppressors of Cytokine Signaling, and Regulation of Insulin-Like Growth Factor I

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider