Why the study?
Does intravenous infusion of N-2-mercaptopropionyl glycine (MPG) reduce myocardial infarct size in a dog model of ischemia-reperfusion injury?
Population
57 dogs undergoing 90 min of ischemia and 48 h of reperfusion
Comparison
Intravenous infusion of N-2-mercaptopropionyl… vs Different timing and duration protocols of MPG…
Design
Preclinical
Follow-up
48 hours
Authors
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Infusion duration critically determines MPG efficacy in canine reperfusion; leaves open optimal regimens and human translation.
Does intravenous infusion of N-2-mercaptopropionyl glycine (MPG) reduce myocardial infarct size in a dog model of ischemia-reperfusion injury?
In a canine model of ischemia-reperfusion, antioxidant therapy with MPG required at least 3 hours of infusion during the first 4 hours of reperfusion to significantly reduce infarct size.
Horwitz et al. (1999) studied this question.
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