What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction. Intervention: N-(2-mercaptopropionyl)-glycine (MPG) vs. Control. Primary outcome: Infarct size normalized for region at risk and collateral blood flow.

April 1, 1994Circulation

Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion.

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Key result

In a canine model of coronary occlusion, infusion of the antioxidant MPG during reperfusion reduced myocardial infarct size by up to 60%.

Why the study?

Does intravenous infusion of the antioxidant N-(2-mercaptopropionyl)-glycine (MPG) reduce infarct size in a canine model of myocardial infarction with reperfusion?

Population

Canine model of myocardial infarction (90 minutes of coronary occlusion followed by 48 hours of reperfusion)

Comparison

Intravenous infusion of N--glycine 100… vs Control group

Design

Preclinical

Follow-up

48 hours

Authors

LHLawrence D. HorwitzUniversity of Colorado Anschutz Medical Campus PFPaul V. FennesseyUniversity of Colorado Hospital RSRobert H. ShikesKaiser Permanente

Discussion

Member takes

Implication

Supports targeting reperfusion injury preclinically; leaves open translation to human myocardial infarction.

Structured PICO

Does intravenous infusion of the antioxidant N-(2-mercaptopropionyl)-glycine (MPG) reduce infarct size in a canine model of myocardial infarction with reperfusion?

Population

Canine model of myocardial infarction undergoing 90 minutes of coronary occlusion and 48 hours of reperfusion.

Intervention

Intravenous infusion of N-(2-mercaptopropionyl)-glycine (MPG) 100 mg.kg-1.h-1, beginning either 15 minutes before the onset of reperfusion or 30 minutes after the onset of reperfusion and continued until 4 hours of reperfusion and followed by an intramuscular dose; or limited to the last 15 minutes of ischemia and the first hour of reperfusion

Comparator

Control group (implied by the comparison of four groups)

Outcome

Infarct size normalized for region at risk and collateral blood flow, measured at 48 hours of reperfusionsurrogate

Prolonged infusion of the antioxidant MPG during reperfusion substantially reduces myocardial infarct size in a canine model, suggesting that reperfusion injury contributes significantly to necrosis.

Cite This Study

Horwitz et al. (1994) studied Myocardial infarction. N-(2-mercaptopropionyl)-glycine (MPG) vs. Control was evaluated on Infarct size normalized for region at risk and collateral blood flow. In a canine model of coronary occlusion, infusion of the antioxidant MPG during reperfusion reduced myocardial infarct size by up to 60%.

synapsesocial.com/papers/6a99c3862a60c81fa4abfa19 https://doi.org/10.1161/01.cir.89.4.1792

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Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider