Why the study?
Do patients with HFNEF have impaired left ventricular contractility compared to healthy controls and HFREF patients as measured by speckle-tracking echocardiography?
Do patients with HFNEF have impaired left ventricular contractility compared to healthy controls and HFREF patients as measured by speckle-tracking echocardiography?
Speckle-tracking echocardiography demonstrates that patients with HFNEF have impaired myocardial contractility, suggesting systolic dysfunction contributes to its pathophysiology more than previously recognized.
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May refine HFNEF phenotyping via contractility measures; leaves open therapeutic implications pending prospective trials.
Yip et al. (2010) studied this question.
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