Sex disparities in the presentation, management and outcomes of patients with acute coronary syndrome: insights from the ACS QUIK trial
Why the study?
Reports on sex differences and inequalities in medical management and cardiovascular disease outcomes in low/middle-income countries are scarce.
Does female sex increase the risk of adverse clinical outcomes in patients presenting with acute coronary syndrome in India?
Population
21 374 patients presenting with ACS in Kerala, India enrolled in the ACS QUIK trial
Comparison
Women vs men
Design
Secondary analysis of a trial cohort
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
Sex-aware ACS pathways may be warranted in LMICs now; leaves open whether targeted QI can close residual outcome gaps.
Structured PICO
Does female sex increase the risk of adverse clinical outcomes in patients presenting with acute coronary syndrome in India?
P
Population
21,374 patients presenting with acute coronary syndrome (ACS) in Kerala, India enrolled in the Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK) trial. Mean age 60, 24.3% women.
I
Intervention
Female sex (observational comparison)
C
Comparator
Male sex
O
Outcome
In-hospital and 30-day major adverse cardiovascular events (MACEs) defined as composite of death, reinfarction, stroke and major bleedingcomposite
Women presenting with ACS in India experience significant delays in care, are less likely to receive guideline-directed therapies, and have a higher risk of in-hospital and 30-day MACE compared to men.
Cite This Study
Khraishah et al. (2021) studied this question.