Population
Caveolin-1-deficient mice and wild-type counterparts, as well as Cav-1 null mouse embryo fibroblasts.
Comparison
Caveolin-1 deficiency with high-fat diet or… vs Wild-type mice.
Design
Preclinical
Follow-up
9 months (for high-fat diet)
Authors
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Caveolin-1 deficiency induces insulin resistance in mice; leaves open its relevance to human metabolic disease.
Caveolin-1 acts as a molecular chaperone necessary for proper stabilization of the insulin receptor in adipocytes in vivo, and its deficiency leads to insulin resistance.
Cohen et al. (2003) studied this question.
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