December 1, 1974Annals of Internal Medicine
Chronic Vasodilator Therapy in the Management of Cardiogenic Shock and Intractable Left Ventricular Failure
Why the study?
Does chronic vasodilator therapy improve heart size and functional status in a patient with cardiogenic shock and intractable left ventricular failure?
Population
1 patient with cardiogenic shock and intractable left ventricular failure due to coronary artery disease
Design
Case_report
Authors
Discussion
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Member takes
Implication
May support vasodilator trial in refractory LV failure; hypothesis-generating case report that leaves efficacy open in cardiogenic shock.
Structured PICO
Does chronic vasodilator therapy improve heart size and functional status in a patient with cardiogenic shock and intractable left ventricular failure?
P
Population
1 patient with cardiogenic shock and intractable left ventricular failure due to coronary artery disease
I
Intervention
21-day infusion of sodium nitroprusside followed by chronic administration of nitrates by mouth and topically
O
Outcome
Heart size and functional status
Chronic reduction of impedance to left ventricular ejection via vasodilator therapy may be a useful approach for severe left ventricular failure.
Cite This Study
Jay N. Cohn (1974) studied this question.