Why the study?
While historically aggressive, some synovial sarcomas are clinically indolent, raising the question of whether tumor grade predicts oncologic outcomes and whether Grade 1 disease exists.
Does synovial sarcoma grade predict oncologic outcomes, and does a low-grade variant exist?
Comparison
Outcomes compared across tumor grades, including a theoretical Grade 1 group
Design
Retrospective review
Authors
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Grade 3 synovial sarcoma was associated with worse metastasis-free survival; supports grading as prognostic but leaves open distinct low-grade variants.
Does synovial sarcoma grade predict oncologic outcomes, and does a low-grade variant exist?
Tumor grade in synovial sarcoma appears to predict oncologic outcomes, with a theoretical Grade 1 group showing improved survival profiles compared to Grades 2 and 3.
Fice et al. (2022) studied this question.
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