Why the study?
Evidence on the relative roles of genes and environment underlying obesity and cardiometabolic disease traits, their correlations, and how they change with age was lacking.
Population
1421 twin pairs from the Chinese National Twin Registry
Comparison
Three age groups: ≤50, 51−60, and >60 years old
Design
Twin study using structural equation models
Authors
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May warrant greater emphasis on modifiable factors with advancing age; leaves open prospective confirmation of declining genetic influence.
Genetic factors play a major role in BMI and cardiometabolic traits, but their influence decreases with age, highlighting the growing importance of environmental factors in older adults.
Hong et al. (2022) studied this question.
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