Key result
Significant genetic variance was observed for blood pressure and cholesterol, with adjusted heritability estimates of 0.64, 0.72, and 0.50 in males, and 0.40, 0.60, and 0.37 in females.
Observational (n=470)
p-value: p=<0.001
Significant genetic variance and heritability exist for systolic and diastolic blood pressure and serum cholesterol in Chinese adolescents, which persist even after adjustment for environmental and anthropometric factors.
Heritability estimates support genetic influences on BP and lipids in Chinese adolescents; leaves open clinical translation pending longitudinal studies.
In order to estimate genetic variance and heritability of systolic blood pressure (SBP), diastolic blood pressure (DBP), serum cholesterol and triglyceride levels, a total of 235 (79 male and 82 female MZ, 41 male and 33 female DZ) twin pairs, recruited from 12 junior high schools in Taipei city, were studied. Statistically significant genetic variance observed for SBP, DBP, serum cholesterol and triglycerides persisted after adjustment for age and anthropometric characteristics. However, further adjustment for dietary preference, beverage consumption, and other host and environmental factors gave different results: genetic variance of adjusted SBP and DBP was still significant, while significance was found only in males for cholesterol and in neither males nor females for triglycerides. Heritability estimates of unadjusted SBP, DBP, cholesterol and triglycerides were 0.27, 0.45, 0.21 and 0.41, respectively, for males, and 0.15, 0.42, 0.41 and 0.82, respectively, for females. After adjustment for age, anthropometric characteristics, host and environmental factors, the heritability estimates of SBP, DBP and cholesterol were 0.64, 0.72 and 0.50, respectively, for males, and 0.40, 0.60 and 0.37, respectively, for females.
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Chen et al. (1984) conducted an observational in Healthy adolescents (Cardiovascular risk factors) (n=470). Genetic variance (Monozygotic vs Dizygotic twins) vs. Dizygotic twins was evaluated on Heritability estimates of systolic blood pressure, diastolic blood pressure, serum cholesterol, and triglycerides (p=<0.001). Significant genetic variance was observed for blood pressure and cholesterol, with adjusted heritability estimates of 0.64, 0.72, and 0.50 in males, and 0.40, 0.60, and 0.37 in females.
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