Why the study?
Does bisoprolol improve tolerability and target dose achievement compared to carvedilol in patients with systolic congestive heart failure?
Does bisoprolol improve tolerability and target dose achievement compared to carvedilol in patients with systolic congestive heart failure?
In unselected patients with systolic heart failure, beta-blocker initiation and titration are poorly tolerated with only a minority reaching target doses, with no significant difference in tolerability between bisoprolol and carvedilol.
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Target doses rarely achieved with either agent in systolic HF; confirms equivalent tolerability and extends evidence on titration barriers.
Galatius et al. (2004) studied this question.
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