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The cis ‐dipyridylcalix[4]pyrrole palladium(II) complex ( cis ‐DPC+Pd 2+ ) forms a cage‐like supramolecular structure that functions as an ion channel, as evidenced by the single ion channel current observations. A lucigenin fluorescence assay revealed that cis ‐DPC+Pd 2+ transports chloride across membranes. The HPTS fluorescence assay revealed that cis ‐DPC+Pd 2+ selectively transports fluoride and chloride. In a cell proliferation assay using THP‐1 cells, the cell survival rate with cis ‐DPC+Pd 2+ was lower than that with trans ‐DPC or trans ‐DPC+Pd 2+ . These results suggest that cis ‐DPC+Pd 2+ causes cell death by forming supramolecular pores, allowing the passage of increased numbers of ions.
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Miyaji et al. (2026) studied this question.
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