Prospective multicenter randomized trial of fast ventricular tachycardia termination by prolonged versus conventional anti-tachyarrhythmia burst pacing in implantable cardioverter-defibrillator patients-Atp DeliVery for pAiNless ICD thErapy (ADVANCE-D) Trial results
Why the study?
Does 15-pulse anti-tachycardia pacing improve termination of fast ventricular tachycardia compared to 8-pulse pacing in patients with an indication for implantable cardioverter-defibrillator?
Population
925 patients with an indication for implantable cardioverter-defibrillator (ICD) implantation
Comparison
Prolonged anti-tachyarrhythmia burst pacing vs Conventional anti-tachyarrhythmia burst pacing
Design
RCT, parallel and randomized
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
15-pulse ATP is not superior to 8-pulse ATP overall for fast VT termination; extends ATP programming data by identifying benefit in preserved LVEF or no-HF subgroups.
Structured PICO
Does 15-pulse anti-tachycardia pacing improve termination of fast ventricular tachycardia compared to 8-pulse pacing in patients with an indication for implantable cardioverter-defibrillator?
P
Population
925 patients with an indication for implantable cardioverter-defibrillator (ICD) implantation
I
Intervention
Prolonged anti-tachyarrhythmia burst pacing (15-pulse ATP)
C
Comparator
Conventional anti-tachyarrhythmia burst pacing (8-pulse ATP)
O
Outcome
Termination of fast ventricular tachycardia episodes
Prolonged 15-pulse ATP is as effective and safe as conventional 8-pulse ATP for terminating fast ventricular tachycardia, with potential added benefit in patients with preserved ejection fraction or no history of heart failure.
Cite This Study
Santini et al. (2010) studied this question.