Incidence of Malformations Since the Introduction of Thalidomide

MEDIALJOURNAL may not always be desirable to instil fluid into the bladder. If chlorhexidine solution is instilled its concen- tration should not exceed-1/5,000, since there is some evidence that stronger solutions-for example, 1/1.000 -may irritate the bladder mucosa (Paterson et al., 1960). Both procedures should therefore be of practical value and preferable to the prophylactic administration of systemic antibiotics, which is likely to breed drug- rcsistant pathogens.