Why the study?
Does Shengmai Injection improve heart function and reduce myocardial ER stress and apoptosis in rats with doxorubicin-induced cardiomyopathy?
Population
Rats with doxorubicin-induced cardiomyopathy (DOX-CM)
Comparison
Shengmai Injection (SMI) vs DOX group (no SMI) and healthy control
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating for SMI in doxorubicin cardiomyopathy; clinical trials needed before human translation.
Does Shengmai Injection improve heart function and reduce myocardial ER stress and apoptosis in rats with doxorubicin-induced cardiomyopathy?
Shengmai Injection improves heart function in a rat model of doxorubicin-induced cardiomyopathy by alleviating myocardial endoplasmic reticulum stress and caspase-12 dependent apoptosis.
Chen et al. (2015) studied this question.
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