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August 15, 2026DEN OpenOpen Access

Update on Sedation for Upper Gastrointestinal Endoscopy in Japan: Current Evidence on Remimazolam

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Authors

RIRyoji IchijimaMTMasahiro ToyamaTSTaiki Shishido

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Overview

Review demonstrates high sedation success and rapid recovery with remimazolam in upper gastrointestinal endoscopy, suggesting a safer alternative to conventional sedatives.

Key Points

  • To review the clinical evidence, efficacy, safety, and positioning of remimazolam for sedation during upper gastrointestinal endoscopy in Japan.
  • Reviewed historical sedation practices in Japan involving midazolam and propofol for gastrointestinal endoscopy.
  • Analyzed Japanese phase III clinical trial outcomes evaluating remimazolam for upper gastrointestinal endoscopy, including elderly cohorts.
  • Remimazolam demonstrated high sedation success rates and rapid recovery profiles during upper gastrointestinal endoscopy across patient age groups.
  • Remimazolam shortened awakening and ambulation times relative to midazolam.
  • Remimazolam was associated with fewer respiratory and cardiovascular adverse events compared to propofol.

Cite This Study

Ichijima et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85dc4https://doi.org/10.1002/deo2.70402
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Remimazolam and Midazolam for Sedation During Endoscopic Retrograde Cholangiopancreatography‐Related Procedures2026 · 2 citations
  2. 2Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial2025
  3. 3Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing colonoscopy: A phase III, investigator-initiated trial2024 · 10 citations
  4. 4Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single‐Center Retrospective Cohort Study2026 · 4 citations
  5. 5Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator‐initiated clinical trial2024 · 19 citations