What question did this study set out to answer?

To evaluate overall survival outcomes and identify clinical risk factors among HIV-infected versus non-HIV-infected patients diagnosed with Hodgkin lymphoma.

August 15, 2026JNCI Cancer SpectrumOpen Access

HIV infection and survival in Hodgkin lymphoma: a real-world analysis of a multicenter research network

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To evaluate overall survival outcomes and identify clinical risk factors among HIV-infected versus non-HIV-infected patients diagnosed with Hodgkin lymphoma.
Retrospective multicenter cohort study analyzing global health records of adults (≥18 years) diagnosed with Hodgkin lymphoma between 2015 and 2025 using the TriNetX database.
HIV-positive and HIV-negative patients (N=927) were matched 1:1 based on age, sex, race, and baseline comorbidities, with overall survival evaluated using Kaplan–Meier and Cox proportional hazards models.
HIV-positive status was associated with significantly inferior overall survival compared to matched HIV-negative controls (HR 1.42; 95% CI 1.10–1.84; p = 0.033).
Among people living with HIV, cerebrovascular disease, hepatitis C virus infection, and chronic kidney disease were independent predictors of increased mortality.
In a matched subgroup receiving ABVD chemotherapy (n = 154 per group), overall survival did not differ significantly between HIV-positive and HIV-negative patients (HR 1.37; 95% CI 0.73–2.56; p = 0.247).

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Implication

Retrospective cohort study finds reduced overall survival in Hodgkin lymphoma patients with HIV, indicating the importance of standard chemotherapy and comorbidity management.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85e69 https://doi.org/10.1093/jncics/pkag076

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Implication

Retrospective cohort study finds reduced overall survival in Hodgkin lymphoma patients with HIV, indicating the importance of standard chemotherapy and comorbidity management.

HIV infection and survival in Hodgkin lymphoma: a real-world analysis of a multicenter research network

Key Points

Discussion

Implication

Cite This Study

HIV infection and survival in Hodgkin lymphoma: a real-world analysis of a multicenter research network

Key Points

Discussion

Implication

Cite This Study

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