Influence of HIV status, age and ethnicity on survival in patients with burkitt lymphoma (BL) and diffuse large B cell lymphoma (DLBCL): A real-world nationwide database study
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Key Points
This study aimed to evaluate the influence of HIV status, age, and ethnicity on survival rates in patients with Burkitt lymphoma and diffuse large B cell lymphoma.
Analysis of data from Cerner Health Facts database from 2013 to 2018
Inclusion of patients diagnosed with Burkitt lymphoma and diffuse large B cell lymphoma
Overall survival calculated from diagnosis to death or hospice discharge
Demographic characteristics were collected and stratified by age and ethnicity
Multivariate cox regression model used to adjust for confounding variables.
315 HIV positive patients among 10,534 total lymphoma patients.
HIV positive DLBCL patients had more than a two-fold higher mortality rate than HIV negative counterparts (HR=2.1).
African American patients with DLBCL faced an almost 40% higher mortality risk than Caucasian patients (HR=1.39).
Patients aged 60-79 years had a 44% higher risk of mortality compared to those aged 40-59 (HR=1.44).
Older patients aged 80 or above had more than double the risk of mortality in the DLBCL cohort (HR=2.16).
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Implication
Nationwide database study finds HIV status and age affect mortality in patients with lymphoma, highlighting disparities.