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Experimental study demonstrates photocatalyst-free decarboxylative Giese amidations under visible light, indicating a sustainable route for scalable flow synthesis.
Previous light-mediated approaches to the direct decarboxylative Giese amidation reaction relied on the use of costly, nonsustainable photocatalysts and faced challenges in efficient scale-up. We have successfully developed a photocatalyst-free, light-mediated methodology via a pathway that is thought to involve in situ EDA formation. The reaction is applicable in batch as well as under flow conditions, including efficient scale-up to gram scale in flow.
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Nickels et al. (2026) studied this question.
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