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In vitro study demonstrates reduced DNA thermal stability in tetramethylammonium chloride, indicating distinct counterion interactions.
Heat denaturation studies of desoxyribonucleic acid in sodium chloride and tetramethylammonium chloride solutions of low ionic strength have shown that DNA melts at a lower temperature in the TMACl solutions. Electrophoresis experiments with DNA in a low ionic strength TMACl medium have disclosed that DNA has only a slightly higher mobility in 0.01 F TMACl than in 0.01 F NaCl.
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Arthur Edward Johnson (2026) studied this question.
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