What question did this study set out to answer?

To review emerging bacterial drug targets, resistance mechanisms, and advanced therapeutic interventions aimed at improving tuberculosis management and overcoming multidrug resistance.

August 15, 2026All LifeOpen Access

A new horizon in tuberculosis control: a review of novel drug targets, mechanisms, and advanced therapeutic strategies

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To review emerging bacterial drug targets, resistance mechanisms, and advanced therapeutic interventions aimed at improving tuberculosis management and overcoming multidrug resistance.
Synthesized literature on Mycobacterium tuberculosis resistance mechanisms, therapeutic regimens, and drug discovery pipelines.
Evaluated novel pharmacological targets, repurposed compounds, host-directed therapies (HDTs), and nanoparticle-based delivery systems.
Identified promising molecular targets, including InhA, KatG, and RpoB, alongside approved therapeutics such as bedaquiline and delamanid for multidrug-resistant and extensively drug-resistant tuberculosis.
Highlighted host-directed therapies, drug repurposing, precision medicine, and nanoparticle-mediated drug delivery as key strategies to reduce regimen duration and systemic toxicity.

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Implication

Review highlights novel drug targets, repurposed agents, and host-directed therapies for resistant tuberculosis, suggesting strategies to meet global End-TB targets.

Cite This Study

Ashaolu et al. (2026) studied this question.

synapsesocial.com/papers/6a8019f175c2e31742c862d6 https://doi.org/10.1080/26895293.2026.2710934

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Implication

Review highlights novel drug targets, repurposed agents, and host-directed therapies for resistant tuberculosis, suggesting strategies to meet global End-TB targets.

A new horizon in tuberculosis control: a review of novel drug targets, mechanisms, and advanced therapeutic strategies

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Discussion

Implication

Cite This Study

A new horizon in tuberculosis control: a review of novel drug targets, mechanisms, and advanced therapeutic strategies

Key Points

Discussion

Implication

Cite This Study

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