Experimental study demonstrates phosphine-mediated divergent cascade cycloaddition of cyclic diketones and terminal alkynes, highlighting a versatile route to complex pyran-fused polycycles.
A facile phosphine-mediated divergent cascade cycloaddition was developed to construct diverse pyran-fused polycycles from cyclic diketones and electron-deficient terminal alkynes. This reaction exhibits alkyne-tuned divergent reactivity and broad functional group compatibility, applicable to both common 2-arylidene-1,3-indanediones and rarely reported alkylidene dibenzo-β-tropolones. A plausible dual-pathway mechanism was proposed to elucidate the divergent reaction process.
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Zhang et al. (2026) studied this question.
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