Why the study?
Does modification of angiotensin II side chains differentially affect binding affinity to AT1 versus AT2 receptors?
Population
Rat AT1 or AT2 receptors expressed in COS1 cell membranes
Comparison
Synthesized analogs of angiotensin II with… vs Comparison between AT1 and AT2 receptor binding
Design
Preclinical
Authors
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Differential side-chain effects should not alter clinical practice; extends molecular basis for AT1/AT2-selective ligand design in future studies.
Does modification of angiotensin II side chains differentially affect binding affinity to AT1 versus AT2 receptors?
The AT2 receptor binds angiotensin II through a 'relaxed' conformation distinct from the constrained AT1 receptor, providing molecular insights into angiotensin receptor pharmacology.
Miura et al. (1999) studied this question.
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