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June 7, 2011Clinical Science

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors

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Population

HEK (human embryonic kidney)-293 cells stably transfected with either AT1R or AT2R

Design

Preclinical

Authors

SBSanja BosnyakDiscovery InstituteEJEmma S. JonesUniversity of LouisvilleACArthur ChristopoulosUniversity of Essex

Discussion

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Overview

Should not change clinical practice; leaves open whether shorter angiotensin peptides act as endogenous AT2R ligands.

Structured PICO

P
Population
HEK (human embryonic kidney)-293 cells stably transfected with either AT1R or AT2R
I
Intervention
Angiotensin peptides (AngII, AngIII, AngIV, Ang-(1-7)), Compound 21, AVE0991, A-779, Candesartan, CGP42214, PD123319
O
Outcome
Binding affinities to AT1R and AT2Rsurrogate

Shorter angiotensin peptides such as AngIV and Ang-(1-7) demonstrate substantial AT2R selectivity over AT1R, suggesting they can act as endogenous ligands at AT2R.

Cite This Study

Bosnyak et al. (2011) studied this question.

synapsesocial.com/papers/6a719a01a528af2d65c423c2https://doi.org/10.1042/cs20110036
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