The article highlights a paradigm shift towards using fixed-dose combination antihypertensive therapies, particularly ARB-based combinations like losartan, as initial treatment for high-risk hypertensive patients.
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May support initial ARB-based fixed-dose combinations in high-risk hypertension; hypothesis-generating and requires RCT confirmation.
The article considers modern approaches to treatment of arterial hypertension. Emphasizes the need for combination antihypertensive therapy, mainly fixed combinations of antihypertensive drugs, patients with high and very high risk already at the start of treatment. Discusses the advantages of combinations of blockers of receptors of angiotensin II to diuretics and calcium antagonists, as well as clinical situations in which these combinations are a priority. Considered the evidence base, pharmacokinetics and clinical benefit of the representative of a class of blockers of receptors for angiotensin II and losartan.
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Остроумова et al. (2015) studied this question.
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