Population
940 hypertensive patients from the Brisighella Heart Study (BHS) cohort of 2329 participants
Design
Cohort
Follow-up
12 years (1984-1996)
Authors
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Observed BP control gains over 12 years should not yet change practice; leaves open causal role of combination therapy in observational data.
Over a 12-year period, blood pressure control in clinical practice significantly improved, driven by increased use of combination therapy and first-line prescription of ACE inhibitors and calcium-channel blockers.
Borghi et al. (2004) studied this question.
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