Why the study?
Does aspirin reduce glomerular filtration rate in healthy humans on severe dietary sodium restriction?
Population
10 healthy human volunteers undergoing severe dietary sodium restriction (10 meq/d)
Comparison
Aspirin vs Baseline state (sodium restriction alone)
Design
Cohort
Authors
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Aspirin was associated with reduced GFR on sodium restriction; hypothesis-generating and should not yet change practice in broader populations.
Does aspirin reduce glomerular filtration rate in healthy humans on severe dietary sodium restriction?
Aspirin significantly depresses glomerular filtration rate in healthy individuals on severe sodium restriction, suggesting caution when prescribing to sodium-restricted patients.
Richard S. Muther (1981) studied this question.
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