Key result
Daily aspirin in healthy rats lowers RBCs, elevates renal enzymes, and causes renal necrosis.
Why the study?
The study investigated the effect of different doses of aspirin on red blood cell parameters, renal functional enzymes, and renal tissue in healthy adult rats.
Does aspirin administration at various doses affect blood parameters and renal tissue in healthy adult rats?
Does aspirin administration at various doses affect blood parameters and renal tissue in healthy adult rats?
Aspirin administration at various doses in rats negatively impacts hematological parameters and renal function, causing structural kidney damage.
Aspirin-related anemia and renal damage in rats should not change practice; leaves open human dose-safety translation.
Acetylsalicylic acid (ASA), usually referred to aspirin, is a nonsteroidal anti-inflammatory medication (NSAID) used as an anticoagulant to treat pain, fever, inflammation and to treat a variety of inflammatory disorders, including Kawasaki disease, pericarditis, and rheumatic fever. In addition to being an antithrombotic, aspirin also lowers the risk of heart attacks. We investigated the effect of aspirin on RBC, Hb, and PCV and renal functional enzyme (urea, Creatinine and uric acid) using different doses of aspirin in healthy adult rats and at the same time clarify its effect on renal tissue. This study included 50 Wistar adult rats were divided into five groups as following; control, G1, G2, G3, and G4, rats in control group drenched distilled water daily, while the rest groups drenched daily with aspirin 30, 70, 100, and150 mg/kg using gastric lavage sequentially. Blood samples were collected from heart for blood parameter and kidney functional enzymes assessment. Kidney tissues were collected for histological process. The results showed decreased in the serum level of RBC, Hb, and PCV; likewise, there was increase in urea and creatinine level. While, there was a decrease in uric acid serum level. In tissue samples, results showed mild atrophy to extensive necrosis in renal tissue samples with cystic dilation in convoluted tubules of the kidney. In summary, current research showed that the use of different aspirin doses over a period of time has a negative impact on blood parameters and renal functional enzymes. Furthermore, the use of aspirin in this way had an adverse effect on renal tissue.
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ALBsateen et al. (2023) studied Healthy (n=50). Aspirin vs. Distilled water was evaluated on Blood parameters (RBC, Hb, PCV), renal functional enzymes (urea, creatinine, uric acid), and renal tissue histology. Daily administration of aspirin at 30 to 150 mg/kg in healthy rats decreased RBC, Hb, and PCV, increased urea and creatinine, and caused mild atrophy to extensive necrosis in renal tissue.
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