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Foundational K+ permeation data in axons; leaves open cardiac channel selectivity questions for targeted therapies.
In 1955, Alan Hodgkin and Richard Keynes published a study whose intent was to answer a rather technical question, but whose result triggered the modern analysis of ion channel permeation ([Hodgkin and Keynes, 1955][1]). They aimed to determine whether the K+ fluxes in giant axons followed the “
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Edwin W. McCleskey (1999) studied this question.
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