March 28, 1986Science

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

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Population

Bovine cardiac sarcolemmal vesicles and skeletal muscle T-tubules incorporated into planar lipid bilayers

Comparison

Electrophysiological recordings under varying… vs Skeletal muscle T-tubule calcium channels

Design

Preclinical

Authors

RRRobert L. RosenbergDrexel University PHPeter HessBoston University JRJohn P. ReevesRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Enables cell-free biophysical study of cardiac Ca channels in animal models; leaves open translation to human physiology or clinical relevance.

Structured PICO

Population

Bovine cardiac sarcolemmal vesicles and skeletal muscle T-tubules incorporated into planar lipid bilayers

Intervention

Electrophysiological recordings under varying ionic conditions (asymmetric vs. identical solutions)

Comparator

Skeletal muscle T-tubule calcium channels

Outcome

Unitary barium or calcium conductances, gating kinetics, and pharmacological responsessurrogate

This study demonstrates that single calcium channels from bovine cardiac sarcolemma can be studied in cell-free planar lipid bilayers, revealing distinct conductance and gating properties compared to skeletal muscle channels.

Cite This Study

Rosenberg et al. (1986) studied this question.

synapsesocial.com/papers/6a79c1301ba4614d7ff3a58e https://doi.org/10.1126/science.2420007

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March 28, 1986Science

Calcium Channels in Planar Lipid Bilayers: Insights into Mechanisms of Ion Permeation and Gating

View Full Paper

Ask AI

Bookmark

Population

Bovine cardiac sarcolemmal vesicles and skeletal muscle T-tubules incorporated into planar lipid bilayers

Comparison

Electrophysiological recordings under varying… vs Skeletal muscle T-tubule calcium channels

Design

Preclinical

Authors

RRRobert L. RosenbergDrexel University PHPeter HessBoston University JRJohn P. ReevesRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Enables cell-free biophysical study of cardiac Ca channels in animal models; leaves open translation to human physiology or clinical relevance.

Structured PICO

Population

Bovine cardiac sarcolemmal vesicles and skeletal muscle T-tubules incorporated into planar lipid bilayers

Intervention

Electrophysiological recordings under varying ionic conditions (asymmetric vs. identical solutions)

Comparator

Skeletal muscle T-tubule calcium channels

Outcome

Unitary barium or calcium conductances, gating kinetics, and pharmacological responsessurrogate

Cite This Study

Rosenberg et al. (1986) studied this question.

synapsesocial.com/papers/6a79c1301ba4614d7ff3a58e https://doi.org/10.1126/science.2420007

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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