Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials.
Population
Bovine cardiac sarcolemmal membranes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not yet influence clinical management; hypothesis-generating for background calcium currents in cardiac physiology.
Structured PICO
P
Population
Bovine cardiac sarcolemmal membranes
I
Intervention
Planar lipid bilayer recordings (with Bay K 8644 for L-type channels)
O
Outcome
Electrophysiological properties of calcium channels (voltage dependence, single-channel conductances, open/closed times)surrogate
This basic science study characterizes cardiac L-type calcium channels in planar lipid bilayers and identifies a novel B-type calcium channel that may contribute to steady background current at negative membrane potentials.
Cite This Study
Rosenberg et al. (1988) studied this question.