Key result
Calcium channels from purified dihydropyridine receptors and intact transverse tubule membranes exhibited two sizes of unitary currents, corresponding to conductances of 7 +/- 1 pS and 16 +/- 3 pS.
Population
Dihydropyridine receptors purified from rabbit skeletal muscle transverse tubule membranes and incorporated…
Comparison
Cadmium and nifedipine vs Intact transverse tubule membranes or baseline…
Design
Preclinical
Authors
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Identifies purified DHP receptor as functional Ca channel in bilayers; leaves open native regulation and clinical relevance.
The presence of two conductance levels in purified dihydropyridine receptors suggests calcium channels may have multiple conductance levels or multiple closely related structural types.
Talvenheimo et al. (1987) studied this question. Purified dihydropyridine receptor preparation vs. Intact transverse tubule membranes was evaluated on Unitary currents and conductances. Calcium channels from purified dihydropyridine receptors and intact transverse tubule membranes exhibited two sizes of unitary currents, corresponding to conductances of 7 +/- 1 pS and 16 +/- 3 pS.
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