December 19, 2013Diabetes and Vascular Disease Research
Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia–reperfusion rat heart
Why the study?
Does vildagliptin reduce infarct size and preserve cardiac function in a rat model of ischaemia-reperfusion injury?
Population
26 rats subjected to 30-min left anterior descending coronary artery occlusion followed by 120-min reperfusion
Comparison
Vildagliptin 2.0 mg/kg intravenously 30 min… vs 1 mL normal saline solution intravenously 30 min…
Design
Preclinical, randomized
Follow-up
120-min reperfusion
Authors
Discussion
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Implication
Should not change clinical practice in acute MI; leaves open translation of rat cardioprotection to human ischaemia-reperfusion injury.
Structured PICO
Does vildagliptin reduce infarct size and preserve cardiac function in a rat model of ischaemia-reperfusion injury?
P
Population
26 rats subjected to 30-min left anterior descending coronary artery occlusion followed by 120-min reperfusion
I
Intervention
Vildagliptin 2.0 mg/kg intravenously 30 min prior to occlusion
C
Comparator
1 mL normal saline solution intravenously 30 min prior to occlusion
O
Outcome
Infarct size, cardiac functions, arrhythmia scores, and mitochondrial functionsurrogate
In a rat model of ischaemia-reperfusion injury, vildagliptin reduced infarct size and preserved cardiac function via mitochondrial protection.
Cite This Study
Chinda et al. (2013) studied this question.