Why the study?
Does vildagliptin improve cardiac function and prevent remodeling in a rat model of post-myocardial infarction heart failure?
Population
Sprague-Dawley rats subjected to coronary ligation to induce myocardial infarction and left ventricular…
Comparison
Vildagliptin 15 mg/kg/day administered either… vs Control and Sham operation.
Design
Preclinical
Follow-up
12 weeks
Authors
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No cardiac benefit with vildagliptin in this post-MI rat model; leaves open whether DPP-4 inhibition aids heart failure remodeling.
Does vildagliptin improve cardiac function and prevent remodeling in a rat model of post-myocardial infarction heart failure?
In a rat model of post-MI heart failure, vildagliptin successfully increased GLP-1 levels but failed to improve cardiac function or attenuate remodeling.
Yin et al. (2011) studied this question.
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