Why the study?
A more differentiated approach to prescribing specific diuretics in antihypertensive therapy, considering effects on endpoints and metabolic profiles, is relevant.
Do thiazide-like diuretics improve cardiovascular outcomes and metabolic safety compared to thiazide diuretics in patients with hypertension?
Do thiazide-like diuretics improve cardiovascular outcomes and metabolic safety compared to thiazide diuretics in patients with hypertension?
Current guidelines and meta-analyses support the preferential use of thiazide-like diuretics over classic thiazides for hypertension, emphasizing a differentiated approach based on metabolic profiles.
Differentiated diuretic choice by endpoints and metabolic effects is now warranted; confirms thiazide-like superiority over thiazides in outcome meta-analyses.
A review of the efficacy and safety of diuretics in hypertension was carried out from the standpoint of current clinical guidelines. Also, updated data from metaanalyzes of the efficacy and metabolic effects of diuretic therapy were reviewed. Currently, a more differentiated approach to the appointment of a specific diuretic as part of antihypertensive therapy, taking into account the effect on endpoints and metabolic effects, seems relevant.
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С. В. Недогода (2021) conducted a review in Arterial hypertension. Thiazide-like diuretics vs. Thiazide diuretics was evaluated. Thiazide-like diuretics, such as indapamide and chlorthalidone, demonstrate advantages over classic thiazide diuretics in reducing cardiovascular endpoints and are preferred in current hypertension guidelines.
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