Why the study?
Does combination haemodynamic and metabolic therapy improve angina control compared to combined haemodynamic therapy in patients with stable angina?
Population
Patients with stable angina inadequately controlled despite optimal haemodynamic monotherapy
Comparison
Combination of haemodynamic and metabolic agents vs Combined haemodynamic therapy
Design
Review
Authors
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May support metabolic add-ons for refractory angina; leaves open need for confirmatory RCTs before practice change.
Does combination haemodynamic and metabolic therapy improve angina control compared to combined haemodynamic therapy in patients with stable angina?
Metabolic agents such as trimetazidine or L-carnitine may provide additional symptomatic benefit when combined with conventional haemodynamic agents for patients with stable angina.
Graham Jackson (2001) studied this question.
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