Why the study?
What factors contribute to bleeding complications associated with warfarin therapy?
What factors contribute to bleeding complications associated with warfarin therapy?
Advanced age, comorbid conditions, and supratherapeutic INR are major factors contributing to bleeding complications in patients on warfarin therapy.
May support closer INR monitoring in older patients with comorbidities; leaves open whether targeted interventions reduce bleeding events.
Purpose This study identified factors that contributed to bleeding complications associated with warfarin therapy that were documented as adverse drug reactions (ADRs). Methods A retrospective chart review was performed using the Medical Records Department's “E” code list of anticoagulant-related ADRs. Descriptive statistics were used to identify common factors associated with bleeding complications related to warfarin use. Results Patients 60 years of age or older experienced 78% of all events; a majority (81%) of reports involved the presence of comorbid conditions such as congestive heart failure, carcinoma, or sepsis. A supratherapeutic INR was documented for 75% of patients with anticoagulant-related ADRS. Conclusions Age, comorbid conditions, and anticoagulation intensity were identified as possible factors contributing to documented ADRs associated with warfarin therapy.
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Bernard et al. (2003) studied this question.
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