Population
Rabbit cardiomyocytes and cardiac/skeletal sarcoplasmic reticulum (SR) microsomes
Design
Preclinical
Authors
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Hypothesis-generating for SERCA/phospholamban modulators; should not yet alter clinical heart failure management.
1-(3,4-dimethoxyphenyl)-3-dodecanone directly stimulates Ca2+-ATPase activity, whereas ellagic acid enhances cardiac SR-Ca2+ uptake by interacting with phospholamban.
Berrebi‐Bertrand et al. (1997) studied this question.
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