Diverse effects of interdialytic intervals on central wave augmentation in haemodialysis patients
Why the study?
Does a long (3-day) interdialytic interval compared to a short (2-day) interval increase central wave augmentation in ESRD patients on haemodialysis?
Population
70 end-stage renal disease (ESRD) patients receiving standard haemodialysis (HD) three times per week
Comparison
Long (3-day) interdialytic interval vs Short (2-day) interdialytic interval
Design
Cohort
Follow-up
3 days and 2 days
Authors
Discussion
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Member takes
Implication
Longer interdialytic intervals associate with greater wave reflection in haemodialysis; hypothesis-generating for excess cardiovascular risk and interval-modification trials.
Structured PICO
Does a long (3-day) interdialytic interval compared to a short (2-day) interval increase central wave augmentation in ESRD patients on haemodialysis?
P
Population
70 end-stage renal disease (ESRD) patients receiving standard haemodialysis (HD) three times per week
I
Intervention
Long (3-day) interdialytic interval
C
Comparator
Short (2-day) interdialytic interval
O
Outcome
Arterial stiffness and wave reflection parameters (AIx, heart-rate-adjusted AIx, augmentation pressure, aortic and brachial PWV)surrogate
A 3-day interdialytic interval significantly increases central wave augmentation compared to a 2-day interval, suggesting a potential mechanism for the elevated cardiovascular risk observed after the long interval in haemodialysis patients.
Cite This Study
Georgianos et al. (2013) studied this question.