Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial
Why the study?
Does blood pressure response to first- and second-line antihypertensive therapies differ among European, African, and South-Asian patients?
Population
4,703 patients from the BP-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial, including…
Comparison
First-line antihypertensive monotherapy and/or… vs Comparison among ethnic groups.
Design
Cohort, Patients were randomized in the ASCOT trial (BP-lowering arm).
Authors
Discussion
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Implication
Ethnic differences in BP response to perindopril add-on should not yet change practice; leaves open confirmation via randomized multi-ethnic trials.
Structured PICO
Does blood pressure response to first- and second-line antihypertensive therapies differ among European, African, and South-Asian patients?
P
Population
4,703 patients from the BP-lowering arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT-BPLA), including European (n=4,368), African (n=203), and South-Asian (n=132) origin patients.
I
Intervention
First-line antihypertensive monotherapy (atenolol or amlodipine) and/or second-line therapy (added thiazide or perindopril).
C
Comparator
Comparison among ethnic groups (European as referent, African, and South-Asian).
O
Outcome
Blood pressure response (defined as end BP minus start of therapy BP).surrogate
Blood pressure responses to first- and second-line antihypertensive therapies vary significantly by ethnicity, highlighting the need for tailored treatment approaches.
Cite This Study
Gupta et al. (2010) studied this question.