Key result
Iron corrole 1-Fe reduces murine atherosclerosis more effectively than natural antioxidants by preventing lipoprotein oxidation.
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Antioxidants that work! The iron corrole 1-Fe (see picture) is a potent catalyst for decomposition of reactive oxygen and nitrogen species that binds selectively to lipoproteins. The complex also affects cholesterol levels and its cellular efflux. 1-Fe is more effective than natural antioxidants in reducing atherosclerosis development in mice. LDL=low-density lipoprotein.
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Haber et al. (2008) studied this question. The iron corrole 1-Fe bound selectively to lipoproteins, rescued them from oxidative damage, and reduced atherosclerosis development in mice more effectively than natural antioxidants.
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