Population
Xenopus oocytes and HEK cells expressing wild-type or modified KV10.1 (KV10.1-BBS) potassium channels
Comparison
Insertion of a bungarotoxin-binding site into… vs Wild-type KV10.1 or mock-transfected cells
Design
Preclinical
Authors
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May guide KV10.1-targeted drug strategies in tumors; leaves open human translation from animal data.
The brief surface half-life and rapid lysosomal targeting of the oncogenic KV10.1 channel are relevant factors for designing drug delivery and targeting strategies against KV10.1 on tumor cells.
Kohl et al. (2011) studied this question.
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