Key result
Kv1.3 translocates to the inner mitochondrial membrane via an unconventional presequence-independent pathway that relies on cytosolic HSP70/HSP90 chaperones and the TIM23 complex.
Why the study?
Although Kv1.3 is functional at both the plasma membrane and inner mitochondrial membrane, the mitochondrial import pathway for Kv1.3 is largely unknown.
Design
Preclinical laboratory study
Authors
Loading...
Reveals TIM23- and chaperone-mediated mitochondrial Kv1.3 routing; extends ion channel biogenesis knowledge while leaving cardiac applications open.
This study elucidates the unconventional mitochondrial import pathway of the Kv1.3 channel, highlighting the role of the TIM23 complex and HSP70/HSP90 chaperones, which may inform future targeted therapies.
Capera et al. (2022) studied this question. HSP70/HSP90 inhibitors and Kv1.3 mutations vs. Vehicle (DMSO) or wild-type Kv1.3 was evaluated on Mitochondrial localization of Kv1.3. Kv1.3 translocates to the inner mitochondrial membrane via an unconventional presequence-independent pathway that relies on cytosolic HSP70/HSP90 chaperones and the TIM23 complex.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: