Why the study?
Does insulin regulate the expression and plasma concentrations of ANGPTL3 and ANGPTL8 in vivo and in vitro?
Does insulin regulate the expression and plasma concentrations of ANGPTL3 and ANGPTL8 in vivo and in vitro?
Insulin decreases plasma ANGPTL3 by decreasing its expression in the liver, while increasing ANGPTL8 in adipose tissue and liver but not in plasma, indicating plasma ANGPTL3 reflects insulin action in target tissues.
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Hyperinsulinemia effects on ANGPTL3/8 are hypothesis-generating; prospective human trials needed before clinical consideration.
Haridas et al. (2015) studied this question.
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