New PET technologies – embracing progress and pushing the limits

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Thanks to companies’ research and development processes, frequently involving fruitful partnerships with academic centres, and what could be acknowledged as welcome competition between PET vendors, new PET hardware and software technologies are regularly innovated and released as clinic-ready products. While some of these technological advancements have gained immediate acceptance from the nuclear medicine and medical physics communities, such as time of flight (ToF), others have not found support for translation. The case of point-spread-function (PSF) modelling within tomographic reconstruction, though unfortunately not unique, is a good representative example of an advanced reconstruction algorithm that has faced controversies, especially in the field of lymphoma imaging, despite numerous studies evaluating its diagnostic performance.