Key result
The combination of myocardial contrast echocardiography and speckle tracking imaging accurately distinguished pathological phases of AMI, with WIR showing an AUC of 0.93 in the inflammatory phase.
Why the study?
The study aimed to provide a non-invasive ultrasound diagnosis strategy using STI and MCE to evaluate myocardial mechanics and microcirculation perfusion and distinguish different pathological phases of AMI.
Does the combination of speckle tracking imaging and myocardial contrast echocardiography accurately distinguish different pathological phases of acute myocardial infarction in a mouse model?
Does the combination of speckle tracking imaging and myocardial contrast echocardiography accurately distinguish different pathological phases of acute myocardial infarction in a mouse model?
The combination of myocardial contrast echocardiography and speckle tracking imaging provides a reliable non-invasive ultrasound strategy to distinguish different pathological phases of acute myocardial infarction in a preclinical model.
Should not yet change AMI staging practice; leaves open human translation of combined STI-MCE phase distinction.
OBJECTIVE: By evaluating the myocardial mechanics and microcirculation perfusion in different pathological phases of acute myocardial infarction (AMI) using speckle tracking imaging (STI) and myocardial contrast echocardiography (MCE). we aim to provide a non-invasive ultrasound diagnosis strategy to distinguish different pathological phases of AMI. METHODS: The C57/BL6 mouse model of acute myocardial infarction (AMI) was created by ligating the left anterior descending coronary artery. Microvessel density (MVD) and pathological changes in the infarct area were analyzed quantitatively and qualitatively using TTC, HE, Masson staining, immunohistochemistry, and immunofluorescence during the inflammatory, proliferative, and mature phases. Global longitudinal strain (GLS), circumferential strain (GCS), and radial strain (GRS) were measured by STI, while myocardial perfusion peak enhancement (PE) and Wish-in-rate (WIR) were measured by MCE. RESULTS: For the inflammatory phase, MVD was 52.8/0.1mm², and inflammatory factors IL-6, IL-1β, and TNFα were up-regulated. WIR showed the best accuracy at this phase, with a value of 12.29 ± 2.24 dB, AUC of 0.93, sensitivity of 1.00, specificity of 0.83, and cut-off of 9.24. For the proliferative phase, MVD dropped to 21.6/0.1mm²; GLS and WIR had high diagnostic performance, with AUCs of 0.89 and 0.97, sensitivities of 0.75 and 1.00, and specificities of 1.00 and 0.91, respectively. In the mature phase, the infarct area became fibrotic, inflammatory factors disappeared, and MVD decreased to 8.6/0.1mm². GRS analysis has diagnostic value, with an AUC of 0.77, sensitivity of 0.91, specificity of 0.66, and a cut-off of 14.36. PE maintained high diagnostic accuracy, with an AUC of 0.93, sensitivity of 1.00, specificity of 0.75, and a cut-off of 5.47. CONCLUSION: The combination of MCE and STI can act as a reliable non-invasive ultrasound diagnosis to distinguish different pathological phases of AMI.
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Wang et al. (2025) studied Acute myocardial infarction. Speckle tracking imaging (STI) and myocardial contrast echocardiography (MCE) was evaluated on Diagnostic accuracy for distinguishing pathological phases of AMI. The combination of myocardial contrast echocardiography and speckle tracking imaging accurately distinguished pathological phases of AMI, with WIR showing an AUC of 0.93 in the inflammatory phase.
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