What question did this study set out to answer?

To review the underlying biological mechanisms, clinical outcomes, and risk factors of osteoporosis, focusing on the diagnostic utility of genetic biomarkers.

November 1, 2018Therapeutics and Clinical Risk ManagementOpen Access

A comprehensive overview on osteoporosis and its risk factors

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To review the underlying biological mechanisms, clinical outcomes, and risk factors of osteoporosis, focusing on the diagnostic utility of genetic biomarkers.
Synthesized published literature on biological alterations, bone structural disruption, and fragility outcomes across diverse ethnic groups.
Evaluated the interplay of environmental factors and genetic variations as potential early diagnostic biomarkers.
Identified progressive alterations in bone biologic material and architecture as the primary causes of severe fragility requiring long-term medical management.
Demonstrated that candidate risk genes serve as promising early diagnosis biomarkers to improve risk stratification for high-risk families.

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Implication

Review highlights genetic and environmental drivers of bone fragility in diverse populations, suggesting gene-based biomarkers for early diagnosis in high-risk individuals.

Cite This Study

Pouresmaeili et al. (2018) studied this question.

synapsesocial.com/papers/6a8083cb0300245a6192a446 https://doi.org/10.2147/tcrm.s138000

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Implication

Review highlights genetic and environmental drivers of bone fragility in diverse populations, suggesting gene-based biomarkers for early diagnosis in high-risk individuals.

A comprehensive overview on osteoporosis and its risk factors

Key Points

Discussion

Implication

Cite This Study

A comprehensive overview on osteoporosis and its risk factors

Key Points

Discussion

Implication

Cite This Study

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