Why the study?
Does testosterone replacement restore baroreflex sensitivity in castrated rats?
Population
Sham-operated rats and castrated rats
Comparison
Testosterone replacement vs Sham-operated rats and castrated rats without…
Design
Preclinical
Follow-up
10 days (duration of castration)
Authors
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Testosterone restores baroreflex sensitivity in castrated rats; leaves open translation to human autonomic regulation or therapy.
Does testosterone replacement restore baroreflex sensitivity in castrated rats?
Testosterone facilitates baroreceptor control of reflex bradycardia, an effect that appears to be autonomically mediated via enhancement of cardiomotor vagal activity.
El‐Mas et al. (2001) studied this question.
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