Why the study?
Does intravenous phenylephrine administered by graded infusion compared to bolus injection alter the measurement of baroreflex sensitivity in normal subjects?
Population
17 normal subjects
Comparison
Intravenous phenylephrine by graded infusion… vs Intravenous phenylephrine by bolus injection…
Design
Other
Authors
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Infusion versus bolus phenylephrine yields discrepant baroreflex slopes; leaves open standardization for clinical or research use.
Does intravenous phenylephrine administered by graded infusion compared to bolus injection alter the measurement of baroreflex sensitivity in normal subjects?
Phenylephrine bolus and infusion methods yield significantly different baroreflex sensitivity values, indicating that the heart rate response to a gradual increase in pressure is less than that seen with a rapid rise.
Sullebarger et al. (1990) studied this question.
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