Why the study?
Does manipulation of arterial blood pressure with nitroprusside or phenylephrine alter patterns of sympathetic neural activation in healthy humans?
Population
22 healthy humans (n=13 for nitroprusside infusion, n=9 for phenylephrine infusion)
Comparison
Intravenous nitroprusside or phenylephrine vs Baseline measurements prior to infusion
Design
Other
Authors
Loading...
Should not change BP management; leaves open hierarchical sympathetic recruitment in disease.
Does manipulation of arterial blood pressure with nitroprusside or phenylephrine alter patterns of sympathetic neural activation in healthy humans?
Manipulation of baroreceptor afferent activity demonstrates a hierarchical pattern of sympathetic neural activation, primarily driven by rate coding of active neurons and recruitment/derecruitment of higher-threshold units.
Limberg et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: